Thyroid Function

always fatigue with high tsh and high TG

Q: high triglycerides but high HDL at the same time, High TSH, Normal T4, I am always tired please explain?

Question: So I went to the doctor because I am always tired. These results came back. What’s weird is that it seems like I have high triglycerides but high HDL at the same time.
Most importantly it seems like something is off with my thyroid because my TSH came back high however my T4 levels are fine.
I would love to know your thoughts here guys.

always fatigue with high tsh and high TG


You should know that some medical tests are not necessarily related to each other.
Fatigue and stress always have several reasons, including, for example:
Most diseases affect the body through physical exhaustion, such as the flu.

If the percentage of fat in the blood (cholesterols and triglycerides) increases, it will be deposited in the blood vessels and cause difficulty in transporting oxygen and food to the tissues of the body, which exhausts the muscles and the body in general.

High TSH may cause thyroid hormones to appear lower than normal, which also causes general lethargy throughout the day and a tendency to drowsiness sometimes.


Q: High T4 High CRP High BUN, what does it mean?

Please explain what in the picture below:


I read the report carefully, however, it would be better if the report has its normal rages, if the universal normal ranges applied to these results I can tell that the child has:

  1. Hyperthyroidism (normal range 6.0 to 12.8, while your child’s level is 17.5): means the thyroid gland is overacting and may lead to unwanted stressful processes in the whole body which explains an irregular and/or unusually fast heart rate (palpitations) and weight loss and irregular bowel movements.
  2. Slight increase in level of blood urea nitrogen as the normal is 2.1 to 7.1 mmol/L, and your child was 7.7.
  3. High CRP: which may be a result of bacteria infection anywhere in the body and its manifestations includes the loss of appetite and pimples, etc.
  4. Normal Ammonia and normal fasting blood glucose.

What Test Shows Why knee Pain When Taking Thyroxine Pills?

Q: My mother takes thyroxine tablets but after many months she feels pain in her knees. how can I solve the reason for knee pain using medical tests?


Thyroxine tablets are the treatment for the under-active thyroid gland, a medical condition in which the thyroid gland secretions are lower than the healthy level, also called hypothyroidism in medical terms.

A simple diagram to illustrate how high TSH causes joint and knee pain
A simple diagram to illustrate how high TSH causes joint and knee pain

When the thyroid gland is under-active, the pituitary gland, also called the master gland, will release TSH hormone as normal feedback to stimulate the thyroid gland, and therefore the proteins deposit in the tissues excessively, because the thyroid gland is responsible for the management of proteins, thus these excessive precipitated proteins cause pain in joints and knees.

So that, the joint and knee pain when taking thyroxine-replacement-therapy is not due to the pills themselves, nevertheless, it is due to high TSH levels.


To know why you have joint and knee pain when on thyroxine treatment you may do thyroid function blood tests (TSH, FT4, and FT3), it might reveal that TSH level is high which can lead to precipitation of proteins and cause pain in joints and knee.