A Blood Test For Liver Function Evaluation with References

If you are looking for a blood test for liver function evaluation, Actually there are 8 tests for liver function testing.
I must explain that liver is a principal organ, many biological process are controlled and managed by liver cells, so hat the liver status can be monitored by many methods and tests.
Take LFTs when you are checking for the liver working status, General checkup in wellness and illness, checkup in pregnancy, and for checking up almost any pain such as Heartburn and difficult urination.
In liver function panel tests we use the chemical substance, “usually enzymes” which synthesized or managed by the liver to check how well he liver cells are working.

A panel of tests used to evaluate liver function. Includes:
Alanine aminotransferase (ALT)
Alkaline phosphatase (ALP)
Aspartate aminotransferase (AST)
Total protein

Liver enzyme testing for General checkup includes ALT, AST, alkaline phosphatase;
Very Specific liver function tests (LFTs) include PT, INR, albumin, and bilirubin.
Used in the evaluation of symptoms associated with liver disease (jaundice, nausea, vomiting and/or diarrhea; loss of appetite;
ascites, hematemesis, melena; fatigue or loss of stamina; history of alcohol or drug abuse).

Who have impaired Liver function and needs for testing?
Persons on a certain medication or a taking pills which cause a shot in their liver test results
Patients with acute or chronic liver illness
Who have signs like Abdominal pain, nausea and vomiting, or yellow skin
Addicts to Alcohols or abuse drugs.
Also Liver enzymes are very sensitive to irritability, allergic reactions, and constipation as well.

Step by step testing for Liver illness and High Enzymes:
AST and ALT is the main tests to assess liver function evaluation in most cases of liver diseases as hepatic inflammation due to viruses, alcohols, and others.
When results come up with elevation in one or both enzymes, more medical tests must be taken for further diagnosis.
Such tests including:
Liver viruses tests: HCV-Ab, HBs-Ag, and HAV-IgM test for Children.
If there is a yellow discoloration of the skin and urine, take a “Bilrubin test”.
If Bilirubin is normal, its ok, if high bilirubin results are shown, then take these tests: Alkaline phosphatase
5′ nucleotidase, or Gamma-glutamyl transpeptidase (GGT), these tests re specific for assess biliary ducts and bile function.
Ultrasound and CT scan to evaluate Liver stones or accumulated fats on the liver which referred as “Fatty Liver”.
If Stones are shown in Scan results, then you must go for urine test and further blood investigations,
If Fats are shown, you must take a fasting blood sample for cholesterol and triglycerides tests.
If Viral testing and Scan show up negative results, take more tests as Alkaline phosphatse and CPK enzymes for assess in bones and muscles issues respectively.
If All results come up Normal, then we may consider the raise in liver enzymes of a transient cause such as Constipation or even unmentioned medication by he patient.

Normal Range and References of main Liver Function Tests:
Alanine aminotransferase (ALT)
10–35 U/L; SI units: 0–0.58 mkat/L
■ Enzyme found in liver cells exclusively.
■ Used in diagnosis of liver, biliary, and pancreatic disease.

Aspartate Aminotransferase (AST)
Adult, child: 0–35 U/L; SI units: 0–0.58 kat/L
Newborn: 15–60 U/L
■ Enzyme found in cardiac muscle, liver, and skeletal muscle.
■ Used primarily to evaluate patients with symptoms of liver disease (jaundice, liver enlargement, fatigue, weight loss, ascites, etc.).

Adult: 3.5–5 g/dL; SI units: 35–50 g/L
Child: 3.8–5.4 g/dL; SI units: 38–54 g/L
■ Main plasma protein; helps maintain osmotic pressure. Decreased albumin causes fluid shifts and resultant edema.
■ Levels decrease in renal or hepatic disease, acute infection,malnutrition, malignancy, diabetes, and many other chronic and acute conditions.

Bilirubin,Total, Direct, Indirect
Adult, child: Total: 0.3–1 mg/dL; SI units: 1.7–20.5 mol/L
Direct: 0.1–0.3 mg/dL; SI units: 1.7–5.1 mol/L
Indirect: 0.1–0.8 mg/dL; SI units: 1.7–12 mol/L
Newborn: 1–12 mg/dL; SI units: 17.1–205 mol/L
Critical Level: Newborn: 15 mg/dL; SI units: 257 mol/L
Bilirubin is a by-product of the the breakdown of hemoglobin.
■ Most bilirubin is chemically attached (conjugated) to another substance. This is called direct bilirubin.  Unconjugated builirubin is called indirect bilirubin. Conjugated bilirubin is excreted in bile.
■ High bilirubin levels cause jaundice and are seen in liver disease and biliary obstruction.
■ In newborns, elevated bilirubin occurs with Rh or ABO incompatibility. Brain jaundice (kernicterus) develops at higher levels and can result in mental retardation, cerebal palsy, or blindness.

Alkaline Phosphatase (ALP)
Adult: 42–136 U/L
Child: 50–230 U/L
■ Enzyme found predominately in the liver, biliary tract, and bone.
■ Useful in assessing liver and bone disease.
■ ALP isoenzymes distinguish between liver and bone disease. ALP1 is hepatic; ALP2 is from bone.

I have to mention some recommendation, the previous explanation is valid if you wan to go for general check up then such information will guide you, if you’re suffering from an illness or unknown pain please book an appointment and get you examined by  a professional doctor.

Dr.Megan Ralf

A Medical laboratory Scientist who devoted his life to medical and laboratory sciences, writes his everyday expertise dealing with various pathological conditions through laboratory diagnosis of different body fluids, also participating in many workshops for first aids, infection control, and urgent care. Also Dr Megan Ralf coaching many medical teams.

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