Blood Test Results Explained

Reading C-Reactive Protein (CRP)

High-T4-High-CRP-High-BUN-levels

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Q: High T4 High CRP High BUN, what does it mean?

Please explain what in the picture below:

Answers:

I read the report carefully, however, it would be better if the report has its normal rages, if the universal normal ranges applied to these results I can tell that the child has:

  1. Hyperthyroidism (normal range 6.0 to 12.8, while your child’s level is 17.5): means the thyroid gland is overacting and may lead to unwanted stressful processes in the whole body which explains an irregular and/or unusually fast heart rate (palpitations) and weight loss and irregular bowel movements.
  2. Slight increase in level of blood urea nitrogen as the normal is 2.1 to 7.1 mmol/L, and your child was 7.7.
  3. High CRP: which may be a result of bacteria infection anywhere in the body and its manifestations includes the loss of appetite and pimples, etc.
  4. Normal Ammonia and normal fasting blood glucose.
is that normal crp 14

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Q: Is CRP 14 mg/L a normal level if I’m having joint pain?

Question:

I’m having joint pain and the CRP test value is 14 mg/l. Is it a normal level?

Answer:

The short answer is No, CRP value of 14 mg/l is not normal but it is not high enough to tell that you have ongoing chronic inflammation, but can tell that the inflammation is fading or weak infection or just a false value that is should be higher, and details are below…

If you test high-sensitive-CRP the normal level is up to 3, hence the 14 is 4 times higher than normal
but if the CRP test is done with the latex method the normal is up to 10, hence 14 is mildly elevated.

CRP levels will rise rapidly within the first 6 to 8 hours after the onset of acute infection and inflammations and CRP reading decrease quickly about 19 hours (a half-life) after initiation of a successful treatment course, and therefore it is a better helpful tool for bacterial infections and antibiotic treatments.

Another thing is that the CRP test may go up too much if there is a tissue inflammation flare-up like in rheumatoid arthritis flare-up.

What causes CRP levels to be slightly higher than normal without inflammation?

  1. Obesity
  2. Lack of exercise
  3. Cigarette smoking
  4. Diabetes

Because CRP is not specific to RA, some people with RA may have normal CRP levels, many other tests can predict the reasons for joint pain better than the general inflammatory markers like the CRP test, such joint pain tests may include:

  1. ACCP and RF tests: which used for investigation if the joint pain is due to rheumatoid arthritis disease.
  2. Sed Rate test: is a better indicator for chronic inflammatori episodes than CRP test.
  3. Uric acid test: which indicating how high is the uric acid in the bloodm which means their are too much uric acid in the blood that can deposit in the joints and cause inflammation and painful sensation, medically called Gout.
  4. Thyroid tests: to investigate if there is Hypothyroidism (underactive thyroid) which responsible for some kind of joint inflammation.
  5. ANA test: to predict if you have any sign of abnormal immunity behaviour or not?
  6. LE cells and dsDNA tests: used for predecting the lupus erythromatosus disease.

X-ray imaging is the first step for diagnosis of joint pain, and using the blood tests comes after that to complete, approve, or exclude the etiological causes.

What causes false-negative CRP levels?

What causes a mild increase in CRP levels while it should be higher?

Certain medicines can falsely cause CRP levels in the blood to be lower than normal or become lower than they should be. These include taking antibiotics, aspirin, steroids, and nonsteroidal anti-inflammatory drugs (NSAIDs) {which are widely used for relieving pain, reduce inflammation, and bring down a high temperature}.

Types of NSAIDs include:

  • ibuprofen.
  • naproxen.
  • diclofenac.
  • celecoxib.
  • mefenamic acid.
  • etoricoxib.
  • indomethacin.

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What is CRP Normal Range (rapid and Hs c-reactive protein normal range)?

CRP normal ranges for adult male and female in healthy stable state, as well as acceptable CRP normal range for children, newborn infants, and pregnant women.
Normal ranges is for quantitative plasma c-reactive protein blood test according to many scientific studies and laboratory observations in many related diseases.
Regular, latex, or rapid CRP blood test used for rheumatoid arthritis screening with references:
Healthy individuals have 0.0 to 0.8 mg/dl normal CRP range or CRP not detected in blood test, CRP normal range for suspected RA or heart diseases is 1.0 – 6.0 mg/dl, CRP range over 10 mg/dl is considered high, and indicate Acute or chronic inflammation.
High sensitivity (Hs-CRP) normal range uses high sensitive detection techniques to measure very tiny amounts of C reactive protein in the blood, Hs CRP is better used in early detection of Heart disease
Normal Hs CRP range for low cardiovascular disease is 0.0 – 1.0 mg/dl, 1.0 and 3.0 mg/L of Hs-CRP is the normal range seen in early average risk for heart disease, Hs-CRP range over 3.0 mg/dl tells a high risk for cardiovascular disease especially with increasing values.
CRP normal range after RA treatment is below 6.0 mg/dl or when CRP values decreasing over treatment course, higher crp may indicate remission or treatment failure.
CRP normal range in infants (healthy full-term and preterm) is from 2 to 5 mg/L during the first few days of life, During the neonatal period upper normal CRP level of 10 mg/L has been identified in many cases. Higher CRP values in infants means sepsis with the help of other tests results.
CRP normal range in pregnancy is from 1.5 – 2.5 mg/dl as observed by many researcher’s studies. CRP normal reference go high in the second half of pregnancy or if woman is on birth control pills. Studies suggest that very high CRP levels in early pregnancy are associated with preterm delivery.
CRP Hs CRP normal chart
CRP is not an independent marker for inflammatory disorders in humans, CRP blood test is a part screening tests include sed rate test, RF, anti-CCP, FBC, ASOT, cardiac enzymes, blood cultures.
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High ASOT test Titre 800 and CRP 30, is that false Positive?

Normal ASOT titre is up to 200 Unit
Titres in this test 200 – 400 – 600 – 800 IU/ml and no higher than 800 IU/ml .
False +ve result may occur in early infection and children between 6 months to 2 years
How to understand Analysis of rheumatic fever, ASOT?
Streptococcus is a type of bacteria infects the tonsils.
Cause pus on the tonsils and increase up to the heart and cause heart problems.
Antistreptolysin O titre is analysis measures the percentage of antibodies formed by the human body against toxins secreted by the streptococcus microbe such as inflammation of the throat or skin.
The ratio begins to increase 7-14 days after injury and then gradually increase the ratio to reach its highest point after about a month of infection and then gradually go down with treatment.
The high titre of the microbe antibodies means just that:
There was inflammation caused by a microbe of tonsils during the last months
High percentage does not mean that there are complications of microbe
A relatively high ASO concentration may remain for four or six months, even without complications
ASO titer could rise with a simple sore throat and only rise does not mean that there are complications will occur or not.
Also nothing to do with the high percentage of the progress of the disease: where the ratio begins to increase after nearly two weeks of infection.
ASOT Analysis does not have an interest in the disease which has now begun,
For example, if the high ASO titre during sore throat, it means Old inflammation and nothing to indicate for the current inflammation.

The importance of ASO test:
When there is the obvious symptoms of Arthritis complications such as redness and swelling and heart problems “and not just the pain of joints.”
When the swelling moving from one joint to another joint within days, only then the aslot test is useful, but ASOT alone is not enough never to diagnose rheumatic disease,
For example, there is a misconception that the high ASO rate is adequate to prove the existence of rheumatic heart disease or arthritis, and another false concept that the high titre means that tonsils need to be eradicated.
Symptoms:
The patient is more vulnerable to flu in addition to the pain in the joints, especially the knee, back, and the inability to walk long distances and this often happens for children and youth.
Finally:
ASO titre more than 600 is need to be proved with clear symptoms and increase in other related blood tests.
High titre means more immunity against arthritis.
CRP concentration is not a valid indicator of Arthritic complications, since C-reactive protein is not associated protein for that, nevertheless, CRP can be raised once or during 24 hours of infection to rapidly tell the body that there are invaders, which called chemotaxis.
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