Q: My 4 Years son has been high IGF 3 hormone for over 2 years now but he isn’t large or growing fast, Is the continuously high IGF3 relevant?

Question:

Is anyone familiar with IGF 3 hormone? My son has been high for over 2 years now but he isn’t large or growing fast. The endocrinologist doesn’t have an explanation. She just keeps saying we will keep an eye on it.
I feel like they are missing something.
He is going to be 4 next week and is 36″ tall. He’s always been in the 3rd percentile or less.
Just looking to see if anyone had any insight.
Thanks
picture of my son next to his 2-year-old cousin

Thank you for taking the time to help explain this. Is the continuously high IGF3 relevant?

Answer:

In medical science, Insulin-like growth factor-1 (IGF-1) hormone along with growth hormone (GH), are the hormones that promote normal growth and development of bone and tissues.

The IGF3 test measures the amount of IGF-1 (also called Insulin-like growth factor binding protein 3 (IGFBP-3)) in the blood. IGF-1 is primarily produced in the liver, skeletal muscles, and many other tissues in response to Growth Hormone stimulation.

Normally, Levels of IGFBP-3 (IGF-1) are of the highest during childhood and puberty and can’t be considered as an abnormal issue, then the Growth hormones levels decrease during adulthood.

It’s good to mention that: Growth hormones levels also may be affected by sexual maturation and nutritional status.

If adults have high IGF hormone levels, they may be diagnosed with acromegaly, a medical term for a case whose body tissues and bones continuously grow more quickly.

Medically, Adolescents during puberty normally have Increased levels of GH and IGF-1 due to the demand for growth and are considered healthy and normal.

Other causes of high IGF hormone without growth needs may include:

Pituitary tumors: usually benign although they show increased levels of insulin-like growth hormone and growth hormone.

In this case: a child has too much growth hormones and normal Thyroid Function Tests while his height is below the recommended tall of the 4 years old boy which is 40 inches on average.

According to the facts we have mentioned above, I can tell that your boy may not have issues in his hormonal levels and the problem can be due to nutritional, neurological, or other causes.

And therefore, more investigations by your doctor are much recommended to ensure that the IGF elevations are of the healthy body functions and not due to abnormalities.

It’s appropriate to tell that Dwarfism is short stature that results from a genetic or medical condition and is generally defined as an adult height of 147 centimeters (4 feet 10 inches) or less.

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